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Experts think the drug could now hold the key to solving the “multiple mechanisms” behind the disease.
The drug, administered by insulin pen, is now being tested on 206 people at 20 UK hospitals with participants undergoing tests to assess its effect on memory and thinking.
Glucose metabolism is one of several disease “markers” with the brain unable to utilise sugar as it takes hold.
A 26-week test on 38 patients – some given a 1.8mg daily dose of the drug and others a placebo – provided “proof in principle” that liraglutide halts the progression of Alzheimer’s.
No previous study has shown such a dramatic effect.
It means the drug could be given to those at risk, or showing the first signs of dementia, to provide a lifetime of normal mental function.
If the results are positive liraglutide – also used as an appetite suppressant and weight loss aid – could be fast-tracked as the first licensed dementia treatment in 12 years.
The trials are led by Dr Paul Edison, consultant physician at Imperial College, London, with results expected in 2018.
Add an ability to burn one confession on a single target for a moderate heal or a shield without the heal.Seems like they just didn't give a f*** since this would definitely put them on par, when tho the RNG aspect is bulls*** overload. Guess which option is not only a huge waste of MP, but also cuts your DPS?See, how can we just sit here and think of much better sounding stuff in less than a day, while SE has a dedicated balancing team, or something close to it, working on all jobs across the board and they all settled on "hey, let's make all their new heals RNG, gated behind spamming spells you should try to avoid spamming, and make that RNG buff need to be stacked 3 times for any real benefit! 600 potency heal that doesn't even heal everyone, and a barrier that's weaker than AST and SCH barriers by an almost funny amount. On that note, it also takes an average of 15 GCDs to build your stacks up to three. It's not just a problem of adding RNG to their mechanics. The problem is that the mechanic tries to trick you into playing suboptimally and then pretending as if a 10% reduced recast time is worth wasting 10 GCDs on. It provides DPS for the party, and it's consistent.Dr Edison said: “If effective, there could be a potential new and safe treatment for Alzheimer’s in the next five years.“From what we have seen it is at least going to stop the progression of the disease.On a practical level, it’s probably the best treatment available.
As chairman of the department of neurology and neurological sciences at Stanford, Longo knows how destructive Alzheimer's can be.